A Self‐Assembled DNA Origami‐Gold Nanorod Complex for Cancer Theranostics

A self‐assembled DNA origami (DO)‐gold nanorod (GNR) complex, which is a dual‐functional nanotheranostics constructed by decorating GNRs onto the surface of DNA origami, is demonstrated. After 24 h incubation of two structured DO‐GNR complexes with human MCF7 breast cancer cells, significant enhancement of cell uptake is achieved compared to bare GNRs by two‐photon luminescence imaging. Particularly, the triangle shaped DO‐GNR complex exhibits optimal cellular accumulation. Compared to GNRs, improved photothermolysis against tumor cells is accomplished for the triangle DO‐GNR complex by two‐photon laser or NIR laser irradiation. Moreover, the DO‐GNR complex exhibits enhanced antitumor efficacy compared with bare GNRs in nude mice bearing breast tumor xenografts. The results demonstrate that the DO‐GNR complex can achieve optimal two‐photon cell imaging and photothermal effect, suggesting a promising candidate for cancer diagnosis and therapy both in vitro and in vivo.     

Highly Sensitive Electro‐Plasmonic Switches Based on Fivefold Stellate Polyhedral Gold Nanoparticles

Electron–photon coupling in metal nanostructures has raised a new trend for active plasmonic switch devices in both fundamental understanding and technological applications. However, low sensitivity switches with an on/off ratio less than 5 have restricted applications. In this work, an electrically modulated plasmonic switch based on a surface‐enhanced Raman spectroscopy (SERS) system with a single fivefold stellate polyhedral gold nanoparticle (FSPAuNP) is reported. The reversible switch of the SERS signal shows high sensitivity with an on/off ratio larger than 30. Such a high on/off ratio arises primarily from the plasmonic resonance shift of the FSPAuNP with the incident laser due to the altered free electron density on the nanoparticle under an applied electrochemical potential. This highly sensitive electro‐plasmonic switch may enable further development of plasmonic devices.     

面向中小企业的起重机云制造设计平台

为提高起重机行业的柔性制造能力,提高企业的快速响应能力与协同配合能力,以云制造理念为基础,利用网络、虚拟化、模块化、参数化等先进技术构建起重机云制造平台.研究了起重机云制造平台的构架及平台的设计流程.通过案例分析详细阐释了起重机云制造平台的运行模式及运作流程.起重机云制造平台的建立,实现了起重机行业的资源整合与资源最大化共享,推动了起重机行业的快速发展.云制造是一种面向中小企业服务的提高效率降低能耗和基于网络化个性化的制造新形式,可以通过网络为中小型企业的制造生产提供及时、全面、质量可靠的各种服务.     

日光对532nm激光成像性能影响实验分析

532 nm激光成像雷达在成像过程中容易受到日光干扰而降低图像信噪比。利用532 nm条纹管激光雷达对复杂场景(建筑物群)进行昼夜成像实验,并采用直方图统计法分析同一场景分别在白昼和夜晚的激光强度像和距离像的像素值分布,进而分析日光对激光成像性能影响。实验结果表明:日照光会提高激光强度像的亮度以及背景/目标的对比度,同时也增加了距离像的空天背景噪声;夜晚激光距离像信噪比高,但目标强度像对比度不佳。     

基于高斯混合势化概率假设密度的脉冲多普勒雷达多目标跟踪算法

为在新兴的随机有限集(RFS)框架下充分利用多普勒信息跟踪杂波环境下的多目标,该文提出基于高斯混合势化概率假设密度(GM-CPHD)的脉冲多普勒雷达多目标跟踪(MTT)算法.该算法在标准GM-CPHD基础上,在使用位置量测更新状态后,再利用多普勒量测进行序贯更新,可获得更精确的似然函数和状态估计.仿真结果验证了该算法的有效性,表明在GM-CPHD基础上引入目标的多普勒信息可有效抑制杂波,显著改善跟踪性能.     

Correlating mobility with social encounters: distributed localization in sparse mobile networks

Wireless Networks - Most existing connectivity-based localization algorithms require high node density which is unavailable in many large-scale sparse mobile networks. By analyzing large datasets...     

Molecular Heterojunctions of Oligo(phenylene ethynylene)s with Linear to Cruciform Framework

Electrical transport properties of molecular junctions are fundamentally affected by the energy alignment between molecular frontier orbitals (highest occupied molecular orbital (HOMO) or lowest unoccupied molecular orbital (LUMO)) and Fermi level (or work function) of electrode metals. Dithiafulvene (DTF) is used as substituent group to the oligo(phenylene ethynylene) (OPE) molecular wires and different molecular structures based on OPE3 backbone (with linear to cruciform framework) are achieved, with viable molecular orbitals and HOMO–LUMO energy gaps. OPE3, OPE3–DTF, and OPE3–tetrathiafulvalene (TTF) can form good self‐assembled monolayers (SAMs) on Au substrates. Molecular heterojunctions based on these SAMs are investigated using conducting probe–atomic force microscopy with different tips (Ag, Au, and Pt) and Fermi levels. The calibrated conductance values follow the sequence OPE3–TTF > OPE3–DTF > OPE3 irrespective of the tip metal. Rectification properties (or diode behavior) are observed in case of the Ag tip for which the work function is furthest from the HOMO levels of the OPE3s. Quantum chemical calculations of the transmission qualitatively agree with the experimental data and reproduce the substituent effect of DTF. Zero‐bias conductance, and symmetric or asymmetric couplings to the electrodes are investigated. The results indicate that improved fidelity of molecular transport measurements may be achieved by systematic studies of homologues series of molecular wires applying several different metal electrodes.     

pH‐ and NIR Light‐Responsive Micelles with Hyperthermia‐Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

The acquisition of multidrug resistance (MDR) is a major hurdle for the successful chemotherapy of tumors. Herein, a novel hybrid micelle with pH and near‐infrared (NIR) light dual‐responsive property is reported for reversing doxorubicin (DOX) resistance in breast cancer. The hybrid micelles are designed to integrate the pH‐ and NIR light‐responsive property of an amphiphilic diblock polymer and the high DOX loading capacity of a polymeric prodrug into one single nanocomposite. At physiological condition (i.e., pH 7.4), the micelles form compact nanostructure with particle size around 30 nm to facilitate blood circulation and passive tumor targeting. Meanwhile, the micelles are quickly dissociated in weakly acidic environment (i.e., pH ≤ 6.2) to release DOX prodrug. When exposed to NIR laser irradiation, the hybrid micelles can trigger notable tumor penetration and cytosol release of DOX payload by inducing tunable hyperthermia effect. In combination with localized NIR laser irradiation, the hybrid micelles significantly inhibit the growth of DOX‐resistant MCF‐7/ADR breast cancer in an orthotopic tumor bearing mouse model. Taken together, this pH and NIR light‐responsive micelles with hyperthermia‐triggered tumor penetration and cytoplasm drug release can be an effective nanoplatform to combat cancer MDR.     

Bioinspired Graphene Actuators Prepared by Unilateral UV Irradiation of Graphene Oxide Papers

Inspired by natural autonomous systems that demonstrate controllable shape, appearance, and actuation under external stimuli, a facile preparation of moisture responsive graphene‐based smart actuators by unilateral UV irradiation of graphene oxide (GO) papers is reported. UV irradiation of GO is found to be an effective protocol to trigger the reduction of GO; however, due to the limited light transmittance and thermal relaxation, thick GO paper cannot be fully reduced. Consequently, by tuning the photoreduction gradient, anisotropic GO/reduced GO (RGO) bilayer structure can be easily prepared toward actuation application. To get better control over the responsive properties, GO/RGO bilayer paper with a certain curvature and RGO patterns are successfully prepared for actuator design. As representative examples, smart humidity‐driven graphene actuators that mimic the cilia of respiratory tract and tendril climber plant are successfully developed for controllable objects transport.